Figure 2From: Stat and interferon genes identified by network analysis differentially regulate primitive and definitive erythropoiesisPutative key regulators of primitive erythropoiesis are differential expressed in primitive versus adult definitive erythropoiesis. 144 genes in the right-tail of the distribution of estimated essentiality scores for the primitive erythroid lineage were found to be differentially expressed compared to the adult definitive erythroid lineage. These genes fall into 6 clusters: A) primitive: preferentially expressed late, definitive: steady-state expression at low levels or not expressed; B) primitive: steady-state expression at low levels or not expressed, definitive: preferentially expressed late; C) preferentially expressed in primitive proerythroblasts; D) primitive: preferentially expressed early and not expressed late, definitive: expression at low levels with some preferential expression in proerythroblasts; E) primitive: preferentially expressed early and not expressed late, definitive: preferentially expressed early and expressed late; and F) primitive: preferential expression early at low levels or not expressed, definitive: preferential expression early or high-levels of steady-state expression. Gene set enrichment analysis identified 56 genes activated downstream of MAPK signaling (†), 11 of which also are downstream effectors of EPO-induced signaling pathways (red). A high-quality version of this image with the heatmap assembled into a single column and cluster dendrogram is available in the Additional file 4: Figure S7.Back to article page