Parameter | Value |
---|
A
| 1.45 |
Γ
1
| 0.0004 |
N
| 0.032 |
C
| 0.044 |
D
0
| 0.013 |
- Here A is the activation rate of Ras ·GTP catalyzed by Cdc25; Γ1 is the affinity of both Cdc25 and Ira1/2 for Ras ·GTP; N is the reaction rate of Ira1/2; C is the production rate of cAMP due to the basal activity of adenylate cyclase; D0 represents the decay rate of cAMP in the absence of activated PDEs.