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Table 2 Parameter values that are consistent when fitting Equations (4a)–(4d) to the Ma et al. data

From: Modeling mutant phenotypes and oscillatory dynamics in the Saccharomyces cerevisiae cAMP-PKA pathway

Parameter Value
A 1.45
Γ 1 0.0004
N 0.032
C 0.044
D 0 0.013
  1. Here A is the activation rate of Ras ·GTP catalyzed by Cdc25; Γ1 is the affinity of both Cdc25 and Ira1/2 for Ras ·GTP; N is the reaction rate of Ira1/2; C is the production rate of cAMP due to the basal activity of adenylate cyclase; D0 represents the decay rate of cAMP in the absence of activated PDEs.