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Figure 3 | BMC Systems Biology

Figure 3

From: Computational modelling of the regulation of Insulin signalling by oxidative stress

Figure 3

Long term effects and effects of inter-subsystem interactions (A) Fasting; Insulin receptors are upregulated during a fast (left panel). Insulin is applied for 15 minutes at the beginning and end of the two-day period (dosing bars at t = 0 and t = 2785 in left panel) producing the effect on the Insulin dose–response curve at the end of the fasting period shown in the right panel; (B) Interaction of Insulin Stimulation and Oxidative stress; Insulin activates glucose uptake strongly; oxidative stress activates it weakly, but reduces the effect of insulin. Data adapted from experiments by Archuleta et al. [17] in rat skeletal muscle; (C) Low oxidative stress increase antioxidant defence, high oxidative stress decreases it. Data adapted from experiments by Essers et al. [44] in human DLD1 human colon carcinoma cells. Both simulation and experiment at t = 960 min (16 h) after exposure.

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