From: Computational modelling of the regulation of Insulin signalling by oxidative stress
Module | Species | Initial value (number of molecules) | Comments & References |
---|---|---|---|
Receptor binding | Ins | 5 × 105, boundary | 10-7 M |
 | InR | 9 × 104 | BioNumbers [37] |
 | Cytoplasm_InR | 1 × 104 | << cell surface |
 | PTP1B | 1 × 105 | assigned (PaxDb suggests PTPN1 5 × 105 in human, 5 × 104 in mouse) http://pax-db.org & [38, 39] |
IRS | IRS1 | 1 × 105 | [26] Appdx B |
 | PI3K | 1 × 104 | [26] Appdx B |
 | PP2A | 5 × 105 | [40] |
Phosphatases | PTEN | 1 × 105 | PaxDb, human |
 | GSH | 100 | assigned |
 | NOX_inact | 100 | assigned |
 | Cytoplasm_SOD2 | 4.17 × 104 | scale 10-3 * PaxDb |
 | Mt | 50 | assigned |
 | extracellular_ROS | 5 × 104, boundary | scale 10-3 * 10 μM |
Akt | Akt | 1 × 105 | [41] |
 | AS160 | 2 × 104 | assigned |
 | PKC | 1 × 105 | assigned same as Akt |
 | PIP2 | 2 × 105 | |
 | PIP3 | 1 × 103 | |
 | cytoplasm_GLUT4 | 9.6 × 104 | Total 1 × 105, assigned ((PaxDb suggests Slc2a4 5 × 104 in mouse) |
 | cellsurface_GLUT4 | 4 × 103 |  |
JNK | JNK | 16000 | PaxDB (Mapk9) |
 | IKK | 2000 | PaxDb (Ikbkb) |
 | DUSP | 1 × 105 | assigned |
FOXO | E2F1 | 300 | assigned, to keep FOXO ~ 1000 |
 | cytoplasm_Foxo1_Pa0 Pd0_Pe0_pUb0 (Foxo with no PTMs) | 1000 | see [34] |