Individual time-series curves (blue lines) and the ensemble average (red line) of key protein concentration for an ensemble of 1000 replicates of the wild type NF-кB signaling system. Computational results are compared side-by-side with population-level experimental data from Ref. . Panel (A): nuclear concentration of NF-кB. Panels (B), (C), (D) are respectively cytoplasmic concentrations of IкBα, IкBβ, and IкBϵ proteins.