Figure 4

Individual time-series curves (blue lines) and the ensemble average (red line) of key protein concentrations are obtained for an ensemble of 1000 replicates of a wild type (A, C) and an A20 knocked-out mutant (B, D). Computational results are compared with population-level experimental data from Ref. [36]. Top panels: nuclear concentration of NF-кB. Bottom panel: IKK concentration.