Table 1 Biochemical reactions and their associated reaction rate constants in the computational model of the NF-κB signaling network

IKKa + IкBα → IKKa:IкBα

Aα

[a]

0.2

[1]

0.1813

IKKa + IкBβ → IKKa:IкBβ

Aβ

[a]

0.05

[3]

0.02997

IKKa + IкBϵ → IKKa:IкBϵ

Aϵ

[a]

0.05

[3]

0.04244

IKKa + IkBα:NF-кB → IKKa:IкBα:NF-кB

Bα

[a]

1

[1]

1.024

IKKa + IkBβ:NF-кB → IKKa:IкBβ:NF-кB

Bβ

[a]

0.25

[3]

0.3683

IKKa + IkBϵ:NF-кB → IKKa:IкBϵ:NF-кB

Bϵ

[a]

0.25

[3]

0.42

NF-кBn → NF-кBn + A20t

C1

[b]

0.0000005

[1]

0.000000506

0 → A20t

C2

[c]

0

[1]

0

A20t → 0

C3

[b]

0.0004

[1]

0.0002438

A20t → A20t + A20

C4

[b]

0.5

[1]

0.5807

A20 → 0

C5

[b]

0.0003

[1]

0.0003769

IKKa:IкBα → IKKa + IкBα

Dα

[b]

0.00125

[2]

0.002046

IKKa:IкBβ → IKKa + IкBβ

Dβ

[b]

0.00175

[2]

0.0005609

IKKa:IкBϵ → IKKa + IкBϵ

Dϵ

[b]

0.00175

[2]

0.002142

IKKa:IкBα:NF-кB → IKKa + IккBα:NF-кB

Dα

[b]

0.00125

[2]

0.002046

IKKa:IkBβ:NF-кB → IKKa + IкBβ:NF-кB

Dβ

[b]

0.00175

[2]

0.000561

IKKa:IкBϵ:NF-кB → IKKa + IкBϵ:NF-кB

Dϵ

[b]

0.00175

[2]

0.002142

IKKa:IкBα:NF-кB → IKKa:IкBα + NF-кB

Eα

[b]

0.000001

[2]

0.00000144

IKKa:IкBβ:NF-кB → IKKa:IкBβ + NF-кB

Eβ

[b]

0.000001

[2]

0.00000124

IKKa:IкBϵ:NF-кB → IKKa:IкBϵ + NF-кB

Eϵ

[b]

0.000001

[2]

0.00000064

IKKa:IкBα + NF-кB → IKKa:IкBα:NF-кB

Fα

[a]

0.5

[2]

0.3789

IKKa:IкBβ + NF-кB → IKKa:IкBβ:NF-кB

Fβ

[a]

0.5

[2]

0.2135

IKKa:IкBϵ + NF-кB → IKKa:IкBϵ:NF-кB

Fϵ

[a]

0.5

[2]

0.3528

IкBα:NF-кB → NF-кB + IкBα

Gα

[b]

0.000001

[2]

0.00000064

IкBβ:NF-кB → NF-кB + IкBβ

Gβ

[b]

0.000001

[2]

0.00000044

IкBϵ:NF-кB → NF-кB + IкBϵ

Gϵ

[b]

0.000001

[2]

0.00000069

IкBαn:NF-кBn → NF-кBn + IкBαn

Gα

[b]

0.000001

[2]

0.00000064

IкBβn:NF-кBn → NF-кBn + IкBβn

Gβ

[b]

0.000001

[2]

0.00000044

IкBϵn:NF-кBn → NF-кBn + IкBϵn

Gϵ

[b]

0.000001

[2]

0.00000069

IкBα + NF-кB → IкBα:NF-кB

Hα

[a]

0.5

[2]

0.4593

IкBβ + NF-кB → IкBβ:NF-кB

Hβ

[a]

0.5

[2]

0.7753

IкBϵ + NF-кB → IкBϵ:NF-кB

Hϵ

[a]

0.5

[2]

0.2895

IкBαn + NF-кBn → IкBαn:NF-кBn

Hα

[a]

0.5

[2]

0.4593

IкBβn + NF-кBn → IкBβn:NF-кBn

Hβ

[a]

0.5

[2]

0.7753

IкBϵn + NF-кBn → IкBϵn:NF-кBn

Hϵ

[a]

0.5

[2]

0.2895

NF-кB → NF-кBn

I1

[b]

0.0025

[1]

0.003037

NF-кBn → NF-кB

K01

[b]

0.00005

[3]

0.00005537

IKKn → IKKa

K1

[b]

0.0025

[1]

0.003273

A20 + IKKa → A20 + IKKi

K2

[a]

0.1

[1]

0.07075

IKKa → IKKi

K3

[b]

0.0015

[1]

0.00202

0 → IKKn

Kprod

[c]

0.000025

[1]

0.000009752

IKKn, IKKa, or IKKi → 0

Kdeg

[b]

0.000125

[1]

0.0001561

Volume ratio of cytoplasm to nucleus

Kv

1

5

[1]

5

IкBαn:NF-кBn → IкBα:NF-кB

Lα

[b]

0.01

[1]

0.013979

IкBβn:NF-кBn → IкBβ:NF-кB

Lβ

[b]

0.005

[3]

0.001567

IкBϵn:NF-кBn → IкBϵ:NF-кB

Lϵ

[b]

0.005

[3]

0.006583

IкBα:NF-кB → NF-кB

Mα

[b]

0.000025

[1]

0.00002837

IкBβ:NF-кB → NF-кB

Mβ

[b]

0.000025

[3]

0.00003609

IкBϵ:NF-кB → NF-кB

Mϵ

[b]

0.000025

[3]

0.00000866

Total NF-кB concentration

NF-кB

[d]

0.06

[1]

0.06

IKKa:IкBα:NF-кB → IKKa + NF-кB

Pα

[b]

0.1

[1]

0.12928

IKKa:IкBβ:NF-кB → IKKa + NF-кB

Pβ

[b]

0.05

[3]

0.06454

IKKa:IкBϵ:NF-кB → IKKa + NF-кB

Pϵ

[b]

0.05

[3]

0.08434

IкBαn → IкBα

Qα

[b]

0.0005

[1]

0.0005123

IкBβn → IкBβ

Qβ

[b]

0.0005

[3]

0.0007398

IkBϵn → IkBϵ

Qϵ

[b]

0.0005

[3]

0.0002184

IKKa:IкBα → IKKa

Rα

[b]

0.1

[1]

0.123

IKKa:IкBβ → IKKa

Rβ

[b]

0.1

[3]

0.03837

IKKa:IкBϵ → IKKa

Rϵ

[b]

0.1

[3]

0.1571

IкBαn:NF-кBn → NF-кBn

Sα

[b]

0.000001

[2]

0.00000037

IкBβn:NF-кBn → NF-кBn

Sβ

[b]

0.000001

[2]

0.000001131

IкBϵn:NF-кBn → NF-кBn

Sϵ

[b]

0.000001

[2]

0.000001037

NF-кBn → NF-кBn + IкBαt

Uα

[b]

0.0000005

[1]

0.000000279

NF-кBn → NF-кBn + IкBβt

Uβ

[b]

0

[2]

0

NF-кBn → NF-кBn + IкBϵt

Uϵ

[b]

0.00000005

[3]

0.000000059

IкBα → IкBαn

Vα

[b]

0.001

[1]

0.0009786

IкBβ → IкBβn

Vβ

[b]

0.001

[3]

0.0004871

IkBϵ → IkBϵn

Vϵ

[b]

0.001

[3]

0.00147

IкBα, IкBαn → 0

Wα

[b]

0.0001

[1]

0.000132

IкBβ, IкBβn → 0

Wβ

[b]

0.0001

[3]

0.000133

IкBϵ, IкBϵn → 0

Wϵ

[b]

0.0001

[3]

0.000042

IкBαt → IkBαt + IkBα

Xα

[b]

0.5

[1]

0.4552

IкBβt → IкBαt + IкBβ

Xβ

[b]

0.5

[3]

0.3828

IкBϵt → IкBαt + IкBϵ

Xϵ

[b]

0.5

[3]

0.3304

0 → IкBαt

Yα

[c]

0.00000005

[3]

0.000000084

0 → IкBβt

Yβ

[c]

0.000000005

[3]

0.00000000414

0 → IкBϵt

Yϵ

[c]

0.000000005

[3]

0.00000000508

IкBαt → 0

Zα

[b]

0.0004

[1]

0.0003375

IкBβt → 0

Zβ

[b]

0.0004

[3]

0.0002031

IкBϵt → 0

Zϵ

[b]

0.0004

[3]

0.0004742