Overview of the hypergraph-based model for constructing higher-order miRNA-mRNA interaction networks at a specific cancer stage. Solid and dotted circles denote miRNAs and mRNAs, respectively. Closed curves denote hyperedges (i.e. modules). In the conventional graph representation (two graphs in the right-bottom of the central box of the figure), ellipses and boxes denote miRNAs and mRNAs, respectively. Grey and white indicate respective high and low gene expression levels.