Biological meaning of mean and variance used in representing a hyperedge. Panels (a) and (b) illustrate how the means and variances differ between low and high discriminative genetic factors. A gene is low-discriminative when the means are similar at each disease stage but the variances are large (where n, p, and m denote normal, primary, and metastatic stage, respectively). Panel (c) illustrates the enhanced discriminative capability of a hyperedge involving two genetic factors. By comparing the discriminative capability of each miRNA or mRNA, the discrimination capability of the hyperedge is enhanced.