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Figure 1 | BMC Systems Biology

Figure 1

From: Sharpening of expression domains induced by transcription and microRNA regulationwithin a spatio-temporal model of mid-hindbrain boundary formation

Figure 1

MHB gene regulatory network and model. (A) Gene regulatory network ofthe six IsO genes considered (adapted from [10]). The two morphogens, which are encoded by Fgf8 andWnt1 are shown as blue circles. Arrows represent activation/productionand bars represent inhibition. (B) Boolean update functions for each node [10]. is the Boolean AND, is the Boolean OR. (C)Partial differential equation model derived from the Boolean update functions [10, 12, 13]. State variables of the macroscopic model of the two-scale process are:u(t,x) = (Otx2(t,x),Gbx2(t,x),Fgf8(t,x),Wnt1(t,x),En(t,x),Pax(t,x))T(cell-specific) andv(t,x) = (Fgf8(t,x),Wnt1(t,x))T(diffusive).

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