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Figure 2 | BMC Systems Biology

Figure 2

From: Integrating Bayesian variable selection with Modular Response Analysis to infer biochemical network topology

Figure 2

Reconstructing the interactions among different modules of the MAPK pathway. Panel (a) shows a simplified representation of the EGF pathway which activates the RAF/MEK/ERK MAPK cascade when stimulated by EGF. The conceptual modules of this pathway is highlighted in Gray. The communicating intermediates of each module are shown in yellow boxes. Panel (b) shows the true interactions among different modules of the MAPK pathway. In this figure, the arrowheads represent activation and the blunt arrowheads represent inhibition. Panel (c) shows the AUROC and AUPR values calculated from the networks which were inferred by BVSA, MRA and SBRA respectively. The error bars depict the standard deviations of the corresponding AUROCs.

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BMC Systems Biology

ISSN: 1752-0509

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