Figure 5

Improvements to the MAP kinase model. The complete list of the improvements needed to generate a functional MAP kinase network (Additional file 4: Table S4). Block numbers indicate the step according to Figure 3C. Step 1 is the translation of the Tiger network to a qualitative model, i.e. changing all quantitative contingencies; “K+” and “K-”, to qualitative contingencies; “!” and “x”. The remaining changes either added reactions (step 2 and 8) or contingencies (step 3, 5 and 8), or altered contingencies (step 4, 6, and 7) or starting states (step 5 and 8).