Figure 7

Stability analysis of the steady state solution in two 2D parameter spaces. (A, C) The color scale represents the absolute value of the imaginary part of the stability eigenvalue with maximum real part, corresponding to the steady state of the system after IFN stimulation, for varying phospho/ dephosphorylation rates (b _ph and b _deph , panel A), and nuclear export/import rates (b _exp and b _imp , panel B). Two distinct dynamic regimes can be identified with this analysis: the damped oscillatory regime (shifted to red) and the overdamped/ non-oscillatory regime (blue). (B, D) Examples of pSTAT1 time evolution in both regimes (damped and over-damped in red/blue lines, respectively) corresponding to parameter position of circle markers for the two diagrams shown in panels A and B, respectively.