Table 2 Parameters for type I IFN ODE model
From: Transient oscillatory dynamics of interferon beta signaling in macrophages
Name | Symbol | Value | Unity |
|---|---|---|---|
Translation rate for STAT1 | b A | 65 | min-1 |
Receptor production rate | b S | 0 | min-1 |
Basal STAT1 RNA | B STAT1 | 0.0062 | min-1 |
Transcription rate for STAT1 | b a | 0.1 | min-1 |
Transcription rate for SOCS1 | b r | 12.8 | min-1 |
Transcription rate for IRF1 | b f | 2.7 | min-1 |
Translation rate for IRF1 | b F | 1.0 · 101 | min-1 |
Translation rate for SOCS1 | b R | 1.0 · 102 | min-1 |
Phosphorylation STAT1 rate | b ph | 1.3 · 103 | min-1 |
Dephosphorylation STAT1 rate | b deph | 0.036 | min-1 |
Import to the nucleus rate (pSTAT1) | b imp | 0.013 | min-1 |
Export from the nucleus rate (STAT1) | b exp | 0.048 | min-1 |
STAT1 phosphorylation activation (Hill’s constant; half maximal activation) | k A | 4680 | molecules |
Dissociation constant for the enzyme-inhibitor by SOCS1 (Hill’s constant; half maximal activation) | k I | 82680 | molecules |
SOCS1 transcription activation by nuclear pSTAT1 (Hill’s constant; half maximal activation) | k r | 23400 | molecules |
IRF1 transcriptional activation by pSTAT1 | k f | 7366 | molecules |
STAT1 transcriptional activation by IRF1 | k F | 1.3 · 105 | molecules |
Cooperativity of SOCS1 protein over STAT1 dimers | q | 4 | Â |
Cooperativity of STAT1 on SOCS1 gene promoter | n | 3 | Â |
Cooperativity of STAT1 on IRF1 gene promoter | m | 2 | Â |
Cooperativity of IRF1 on STAT1 gene promoter | u | 1 | Â |
Receptor internalization/degradation rate | λ S | 0.0229 | min-1 |
SOCS1 RNA degradation rate | λ r | 0.0347 | min-1 |
SOCS1 protein degradation rate | λ R | 0.0231 | min-1 |
IRF1 RNA degradation rate | λ f | 0.0173 | min-1 |
IRF1 protein degradation rate | λ F | 0.0116 | min-1 |
STAT1 RNA degradation rate | λ a | 0.0058 | min-1 |
STAT1 protein degradation rate | λ STAT | 0.0007 | min-1 |