From: Computational modelling of bovine ovarian follicle development
Parameter | Simulation value | Reference value | References | |
---|---|---|---|---|
Parameter values directory from the literature | Λ(0) | 5 mm | 4-5 mm | [20] |
v | 2.3 × 10−5 mm s−1 | ∼10 mm in 5 days | [20] | |
D H | 6.7 × 10−5 mm2 s−1 | Average 6.7 × 10−5 mm2 s−1 for FSH | ||
D S | 10−4 mm2 s−1 | Small molecule Diff coeff 10−4 mm2 s−1 | ||
| 2 × 10−8 mm2 s−1 | 1.9 ± 1 × 10−8 mm2 s−1 | [25] | |
D R | 10−7 mm2 s−1 | 10−9−5×10−7 mm2 s−1 | ||
D I | 4 × 10−9 mm2 s−1 | IGF receptor complex almost immobile | [26] | |
k on | 10−3 nM−1s−1 | Standard value | [30] | |
| 5 × 10−4 s−1 | Average: K D = 5 × 10−10M−1 | ||
| 10−2 s−1 | K D = 9 nM | [37] | |
| 10−4 s−1 | K D = 0.1 nM | [38] | |
δ F | 10−5 s−1 | Half-life of FSH in ovariectomized ewes is 20 h | [39] | |
δ L | 5 × 10−4 s−1 | Half-life of LH in ovariectomized rats is 23 minutes | [40] | |
| 3 × 10−5 s−1 | Measured decay rate 3 × 10−5 s−1 | [41] | |
| 7.5 × 10−4 s−1 | Half-life LH/hCG-bound receptor 17 min | ||
| 6.4 × 10−5 s−1 | Half-life is about 3 hours | ||
δ I | 1.2 × 10−6 s−1 | Half-life ∼ 10 hours | ||
| 500 × 0.5 pM s−1 | 21 receptors/cell/min = 500 × 0.5 pM s−1 | ||
ρ E | 0.06 s−1 | k cat = 0.06 s−1 | ||
K M | 44 nM | K M = 44 nM | ||
ρ F | 2 nM | FSH concentration ∼ 2 nM, flux Δ = 1 s−1 | [55] | |
ρ L | 0.4 ρ F | LH concentration 40 % of that of FSH | [56] | |
Adapted |
| 1.25 pM s−1 | 45000 estrogen receptors are detected per cell | [57] |
ρ I | 2.8 K I δ I | Reproduce measured granulosa LH receptor numbers (≤ 3 nM) | [7] | |
ρ A | 100 nM | Reproduce androgen concentration in follicular fluid | ||
K I | 5 μ M | Reproduce estradiol concentration in follicular fluid | ||
Figure3 | K L | 500 × 10 pM | Reproduce steepness of expression kinetics in Figure3A | Figure3A |
K F | 500 × 3 nM | Reproduce steepness of expression kinetics in Figure3B | Figure3B | |
K E | 35 nM | Reproduce steepness of expression kinetics in Figure3B | Figure3B | |
ϑ | 0.2 | Reproduce ordinate intercept in Figure3C | Figure3C | |
I(0) | 0.3K I Θ | Reproduce ordinate intercept in Figure3A | Figure3A |