A novel function prediction approach using protein overlap networks

BMC Systems Biology

Table 2 Results of protein function prediction with a single-genome PON

	Success rate^a(%)	Predictable^b(%)	Coverage^c(%)	Top 1	Top 3
	Success rate^a(%)	Predictable^b(%)	Coverage^c(%)	accuracy^d(%)	accuracy^e(%)
Yeast	30.2	37.1	33.9	34.0	63.0
Fly	34.2	54.1	47.4	37.5	59.6
Worm	32.6	53.0	38.3	36.0	61.0
Human	40.0	68.3	55.8	43.3	70.4

^aPercentage of correctly predicted GO terms averaged throughout the whole genome.
^bA node was predictable if its neighboring nodes were annotated with at least one GO term.
^cPercentage of predictable and annotated nodes.
^dThe GO term with the highest frequency of occurrence was evaluated.
^eThe best of the top 3 predictions was evaluated in cases that neighboring nodes were annotated with at least three GO terms.

ISSN: 1752-0509