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Figure 6 | BMC Systems Biology

Figure 6

From: Bridging the gap between gene expression and metabolic phenotype via kinetic models

Figure 6

Predicted metabolic response of S. cerevisiae to different weak organic acids. Both panels show the sum of squared errors (SSE) of the predicted exchange fluxes and biomass yield normalized using the SSE between the experimental values for the reference and the corresponding treated culture. (A) Response of the treated cultures predicted using the corresponding gene expression data (GED) or assuming no gene expression changes (No GED). The predictions of the treated cultures using gene expression data correspond to the data in Table 3. (B) Predicted response of cultures under the reference condition with the expression level of the untreated culture (No GED) or with the gene expression levels of the treated cultures (GED). For simulations in (B), we set the extracellular glucose and biomass concentrations to the experimental reference values.

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