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Table 1 Fitting parameters for the kinetic model of S. cerevisiae metabolic network

From: Bridging the gap between gene expression and metabolic phenotype via kinetic models

Parameter

Comment

Valuea

  

3-ATb

WOAc

α

Kinetic order for biomass drain fluxes

1.00×10-1

1.00×10-1

β d

Ratio of the forward (or backward if reference flux is negative) reaction rate

3.00×101

3.00×101

to the overall rate of the reversible reactions

γ

Correction factor for biomass growth rate

9.80×10-1

1.00×100

k ser→gly

Inhibition factor of the synthesis of glycine from serine by 3-AT

2.27×10-2

-

k his

Inhibition factor of the synthesis of histidine 3-AT

4.87×10-1

-

r WOA

WOA uptake rate

-

3.00×101

  1. a All parameters are dimensionless.
  2. b Parameter values for simulating the response of S. cerevisiae to 3-aminotriazole (3-AT).
  3. c Parameter values for simulating the response of S. cerevisiae to weak organic acids (WOA).
  4. d Reversibility of the reactions was based on the designations in the model by Moxley et al. [25] and the KEGG database (http://www.genome.jp/kegg/).