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Table 3 Predicted metabolic responses to weak organic acid treatments

From: Bridging the gap between gene expression and metabolic phenotype via kinetic models

Fluxa

Reference

Treatment

  

Acetate

Benzoate

Propionate

Sorbate

 

Exp.b

Exp.

Sim.

Exp.

Sim.

Exp.

Sim.

Exp.

Sim.

Glucose

6.09

12.23

12.31

12.26

12.11

12.92

12.67

12.12

11.95

CO2

10.45

22.54

22.58

21.80

21.67

24.09

22.89

20.76

21.55

Ethanol

9.60

21.23

21.39

20.61

20.72

21.60

21.79

20.18

20.63

Glycerol

0.79

0.54

1.56

0.96

1.43

1.00

1.56

0.83

1.28

Lactate

0.05

0.09

0.06

0.10

0.06

0.11

0.07

0.09

0.06

Acetate

0.02

−0.57

−0.58

0.08

0.11

0.03

0.12

0.02

0.11

C-recov.

99.41

95.14

98.71

95.68

98.60

96.48

99.24

93.47

98.91

Yield

0.09

0.05

0.04

0.05

0.05

0.04

0.04

0.05

0.05

  1. aFluxes from Glucose to Acetate correspond to exchange fluxes in mmol·g-1·h-1; C-recov. denotes the percentage of carbon recovered in the measured exchange fluxes and biomass (we attributed the lost carbon to pyruvate secretion); Yield denotes the production of biomass per unit of consumed substrate (g·g-1).
  2. b Experimental (Exp.) data taken from Abbott et al. [24]. Simulated data are denoted by Sim.
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BMC Systems Biology

ISSN: 1752-0509

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