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Table 5 Contribution to tolerance to weak organic acid (WOA) treatment and gene expression changes of the two most important reactions

From: Bridging the gap between gene expression and metabolic phenotype via kinetic models

Reaction

Treatment

NUCa

gb(rankingc)

EC 2.7.1.1 (Glucose → Glucose-6P)

Acetate

0.91

7.4 (3)

 

Benzoate

0.56

2.4 (3)

 

Propionate

0.64

5.9 (2)

 

Sorbate

0.31

1.4 (35)

EC 4.1.1.1 (Pyruvate → Acetaldehyde)

Acetate

0.16

1.4 (28)

 

Benzoate

0.22

1.4 (21)

 

Propionate

0.48

4.1 (6)

 

Sorbate

0.41

1.6 (15)

  1. a NUC: normalized uptake change. See Figure 8A for the definition of NUC.
  2. b Overall gene expression changes associated with the reaction computed from the gene expression data taken from Abbott et al. [24].
  3. c Ranking among the 96 reactions associated with at least one gene, sorted by decreasing level of gene expression changes (absolute value of the log2 expression ratio).
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BMC Systems Biology

ISSN: 1752-0509

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