Figure 3
From: Modeling heterogeneous responsiveness of intrinsic apoptosis pathway
Two-parameter bifurcation diagrams of the modified model of intrinsic apoptosis pathway. Bifurcation analysis of our deterministic model against pairs among four selected parameters, namely Hill Constant in the positive feedback loop (K c ), cooperativity in the activation of CEA (n), degradation rate of caspase 9 (μ5), and rate constant of the inhibition of CEA by IAP (k u ). 2D bistability diagrams are plotted with respect to K c and k u (A), K c and μ5(B), K c and n (C), n and k u (D), n and μ5(E), μ5 and k u (F). The gray area depicts the location of paired parameter values at which the CEA response is bistable.