Figure 5
From: Modeling heterogeneous responsiveness of intrinsic apoptosis pathway
Effect of intrinsic noise on the stochasticity of steady-state CEA response. Stochastic model of intrinsic apoptosis pathway subject to intrinsic noise is simulated under the eight copy-number conditions of c9p = {5×103,104} combined with c3p = {10,102,103,104}. (A) Mean level of the steady-state CEA response is plotted versus the input signal CC (cross: simulation data; solid line: fitted curve). Calculation is based on 150 cells at each data point. The color scheme of specific copy-number condition of [c9p, c3p] is as follows: magenta for [ 5×103,10]; cyan for [ 5×103,102]; orange for [ 5×103,103]; red for [ 5×103,104]; blue for [ 104,10]; green for [ 104,102]; gray for [ 104,103]; black for [ 104,104]. (B) Standard deviation of the steady-state CEA response is plotted versus the input signal CC (cross: simulation data; solid line: fitted curve). The same color scheme as (A) is used. (C) The coefficient of variation (CV) of the steady-state CEA response is plotted versus the input signal of CC (cross: simulation data; solid line: fitted curve). All the calculation is based on 150 cells at each data point. The same color scheme as (A) is used.