Figure 6From: Modeling heterogeneous responsiveness of intrinsic apoptosis pathwayEffect of intrinsic noise on the stochasticity of the time delay of CEA response. Stochastic model of intrinsic apoptosis pathway subject to intrinsic noise is simulated under the eight copy-number conditions of c9p = {5×103,104} combined with c3p = {10,102,103,104}. (A) The time delay of CEA activation, denoted as T d , is defined as the time it takes to reach half maximal of the mean steady-state value of CEA response. (B) The mean value of T d is plotted versus the input signal CC (cross: simulation data; solid line: fitted curve). The color scheme of specific copy-number condition of [c9p, c3p] is as follows: magenta for [ 5×103,10]; cyan for [ 5×103,102]; orange for [ 5×103,103]; red for [ 5×103,104]; blue for [ 104,10]; green for [ 104,102]; gray for [ 104,103]; black for [ 104,104]. (C) The cell-to-cell stochasticity of T d represented by the coefficient of variation of T d is plotted versus the input signal CC in the range of 0 to 600 number of molecules (cross: simulation data; solid line: fitted curve). The same color scheme as (B) is used. (D) The coefficient of variation (CV) of T d is plotted versus CC in the range of 0 to 10,000 number of molecules (cross: simulation data; solid line: fitted curve). The same color scheme as (B) is used. All the calculation is based on 150 cells at each data point.Back to article page