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Figure 6 | BMC Systems Biology

Figure 6

From: Modeling heterogeneous responsiveness of intrinsic apoptosis pathway

Figure 6

Effect of intrinsic noise on the stochasticity of the time delay of CEA response. Stochastic model of intrinsic apoptosis pathway subject to intrinsic noise is simulated under the eight copy-number conditions of c9p = {5×103,104} combined with c3p = {10,102,103,104}. (A) The time delay of CEA activation, denoted as T d , is defined as the time it takes to reach half maximal of the mean steady-state value of CEA response. (B) The mean value of T d is plotted versus the input signal CC (cross: simulation data; solid line: fitted curve). The color scheme of specific copy-number condition of [c9p, c3p] is as follows: magenta for [ 5×103,10]; cyan for [ 5×103,102]; orange for [ 5×103,103]; red for [ 5×103,104]; blue for [ 104,10]; green for [ 104,102]; gray for [ 104,103]; black for [ 104,104]. (C) The cell-to-cell stochasticity of T d represented by the coefficient of variation of T d is plotted versus the input signal CC in the range of 0 to 600 number of molecules (cross: simulation data; solid line: fitted curve). The same color scheme as (B) is used. (D) The coefficient of variation (CV) of T d is plotted versus CC in the range of 0 to 10,000 number of molecules (cross: simulation data; solid line: fitted curve). The same color scheme as (B) is used. All the calculation is based on 150 cells at each data point.

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