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Figure 8 | BMC Systems Biology

Figure 8

From: Modeling heterogeneous responsiveness of intrinsic apoptosis pathway

Figure 8

Effect of extrinsic noise in the amount of IAP protein on the stochasticity of the time delay of CEA response. (A) Stochastic model of intrinsic apoptosis pathway under the extrinsic noise of random amount of IAP protein is implemented by simulating the deterministic model, while assuming the mean concentration of IAP is log-normally distributed with a coefficient of variation CV = 0.25 across cells. Coefficient of variation (CV) of the time delay of CEA activation, T d , is shown as 2D heat map versus the mean concentration of IAP protein at various concentrations of Cytochrome C (CC). The superimposed curves are the low (dashed lines) and high (solid lines) thresholds of the bistability diagram of the corresponding stochastic model (black color) as well as the deterministic model (gray color). The blank region means zero CV of T d as all the CEA trajectories have zero steady-state value. (B) Stochastic model under the extrinsic noise of random amount of both IAP and CC proteins is implemented by simulating the deterministic model, while assuming the concentrations of both CC and IAP are log-normally distributed with a coefficient of variation CV = 0.25 across cells. Coefficient of variation (CV) of the time delay of CEA activation, T d , is shown as 2D heat map versus the mean concentration of the IAP protein and that of the CC protein. Again, the superimposed curves are the low (dashed lines) and high (solid lines) thresholds of the bistability diagram of the corresponding stochastic model (black color) as well as the deterministic model (gray color).

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