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Table 2 Nominal parameter values of the deterministic model, which are proposed based on the Fussenegger et al model [20]

From: Modeling heterogeneous responsiveness of intrinsic apoptosis pathway

Deterministic model parameter values

Parameter

Description

Unit

Value

k f 1

Binding rate constant for Cytochrome C and Apaf-1

m i n −1

0.12

k f 2

Catalysis rate constant for c9a

μ M−1·m i n−1

0.3

k f 3

Catalysis rate constant for CEA

μ M−1·m i n−1

0.015

k r 1

Unbinding rate constant for Cytochrome C and Apaf-1

m i n −1

0.4

K H

Equilibrium rate constant for binding of Cytochrome C and Apaf-1

μ M −1

1

K K

Equilibrium constant for binding of c9p and Apoptosome

μ M −1

0.5

K L

Equilibrium constant for binding of c9p and Apoptosome

μ M −1

0.3

K P

Equilibrium constant for binding of c9a and c3p

μ M −1

0.1

K U

Equilibrium constant for binding of IAP and CEA

μ M −1

0.1

k u

Inhibition rate constant of CEA by IAP

μ M−1·m i n−1

0.03

I A P

Concentration of free IAP protein

μ M

0.018

K c

Threshold concentration for catalysis of c9p by CEA

μ M

0.1

μ 1

Degradation rate constant for the complex of Cytochrome C and Apaf-1

m i n −1

0.005

μ 2

Degradation rate constant for c9p

m i n −1

0.005

μ 3

Degradation rate constant for c9a

m i n −1

0.005

μ 4

Degradation rate constant for c3p

m i n −1

0.005

μ 5

Degradation rate constant for CEA

m i n −1

0.005

Ω E Z

Basal synthesis rate for c3p

μ M·m i n−1

0.05

Ω9

Basal synthesis rate for c9p

μ M·m i n−1

0.05