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Table 2 Nominal parameter values of the deterministic model, which are proposed based on the Fussenegger et al model [20]

From: Modeling heterogeneous responsiveness of intrinsic apoptosis pathway

Deterministic model parameter values
Parameter Description Unit Value
k f 1 Binding rate constant for Cytochrome C and Apaf-1 m i n −1 0.12
k f 2 Catalysis rate constant for c9a μ M−1·m i n−1 0.3
k f 3 Catalysis rate constant for CEA μ M−1·m i n−1 0.015
k r 1 Unbinding rate constant for Cytochrome C and Apaf-1 m i n −1 0.4
K H Equilibrium rate constant for binding of Cytochrome C and Apaf-1 μ M −1 1
K K Equilibrium constant for binding of c9p and Apoptosome μ M −1 0.5
K L Equilibrium constant for binding of c9p and Apoptosome μ M −1 0.3
K P Equilibrium constant for binding of c9a and c3p μ M −1 0.1
K U Equilibrium constant for binding of IAP and CEA μ M −1 0.1
k u Inhibition rate constant of CEA by IAP μ M−1·m i n−1 0.03
I A P Concentration of free IAP protein μ M 0.018
K c Threshold concentration for catalysis of c9p by CEA μ M 0.1
μ 1 Degradation rate constant for the complex of Cytochrome C and Apaf-1 m i n −1 0.005
μ 2 Degradation rate constant for c9p m i n −1 0.005
μ 3 Degradation rate constant for c9a m i n −1 0.005
μ 4 Degradation rate constant for c3p m i n −1 0.005
μ 5 Degradation rate constant for CEA m i n −1 0.005
Ω E Z Basal synthesis rate for c3p μ M·m i n−1 0.05
Ω9 Basal synthesis rate for c9p μ M·m i n−1 0.05