From: Modeling heterogeneous responsiveness of intrinsic apoptosis pathway
Deterministic model parameter values | |||
---|---|---|---|
Parameter | Description | Unit | Value |
k f 1 | Binding rate constant for Cytochrome C and Apaf-1 | m i n −1 | 0.12 |
k f 2 | Catalysis rate constant for c9a | μ M−1·m i n−1 | 0.3 |
k f 3 | Catalysis rate constant for CEA | μ M−1·m i n−1 | 0.015 |
k r 1 | Unbinding rate constant for Cytochrome C and Apaf-1 | m i n −1 | 0.4 |
K H | Equilibrium rate constant for binding of Cytochrome C and Apaf-1 | μ M −1 | 1 |
K K | Equilibrium constant for binding of c9p and Apoptosome | μ M −1 | 0.5 |
K L | Equilibrium constant for binding of c9p and Apoptosome | μ M −1 | 0.3 |
K P | Equilibrium constant for binding of c9a and c3p | μ M −1 | 0.1 |
K U | Equilibrium constant for binding of IAP and CEA | μ M −1 | 0.1 |
k u | Inhibition rate constant of CEA by IAP | μ M−1·m i n−1 | 0.03 |
I A P | Concentration of free IAP protein | μ M | 0.018 |
K c | Threshold concentration for catalysis of c9p by CEA | μ M | 0.1 |
μ 1 | Degradation rate constant for the complex of Cytochrome C and Apaf-1 | m i n −1 | 0.005 |
μ 2 | Degradation rate constant for c9p | m i n −1 | 0.005 |
μ 3 | Degradation rate constant for c9a | m i n −1 | 0.005 |
μ 4 | Degradation rate constant for c3p | m i n −1 | 0.005 |
μ 5 | Degradation rate constant for CEA | m i n −1 | 0.005 |
Ω E Z | Basal synthesis rate for c3p | μ M·m i n−1 | 0.05 |
Ω9 | Basal synthesis rate for c9p | μ M·m i n−1 | 0.05 |