From: Modeling heterogeneous responsiveness of intrinsic apoptosis pathway

Deterministic model parameter values | |||
---|---|---|---|

Parameter | Description | Unit | Value |

k
_{f 1}
| Binding rate constant for Cytochrome C and Apaf-1 |
m
i
n
^{−1}
| 0.12 |

k
_{f 2}
| Catalysis rate constant for c9a |
μ M^{−1}·m i n^{−1}
| 0.3 |

k
_{f 3}
| Catalysis rate constant for CEA |
μ M^{−1}·m i n^{−1}
| 0.015 |

k
_{r 1}
| Unbinding rate constant for Cytochrome C and Apaf-1 |
m
i
n
^{−1}
| 0.4 |

K
_{
H
}
| Equilibrium rate constant for binding of Cytochrome C and Apaf-1 |
μ
M
^{−1}
| 1 |

K
_{
K
}
| Equilibrium constant for binding of c9p and Apoptosome |
μ
M
^{−1}
| 0.5 |

K
_{
L
}
| Equilibrium constant for binding of c9p and Apoptosome |
μ
M
^{−1}
| 0.3 |

K
_{
P
}
| Equilibrium constant for binding of c9a and c3p |
μ
M
^{−1}
| 0.1 |

K
_{
U
}
| Equilibrium constant for binding of IAP and CEA |
μ
M
^{−1}
| 0.1 |

k
_{
u
}
| Inhibition rate constant of CEA by IAP |
μ M^{−1}·m i n^{−1}
| 0.03 |

I
A
P
| Concentration of free IAP protein |
μ
M
| 0.018 |

K
_{
c
}
| Threshold concentration for catalysis of c9p by CEA |
μ
M
| 0.1 |

μ
_{1}
| Degradation rate constant for the complex of Cytochrome C and Apaf-1 |
m
i
n
^{−1}
| 0.005 |

μ
_{2}
| Degradation rate constant for c9p |
m
i
n
^{−1}
| 0.005 |

μ
_{3}
| Degradation rate constant for c9a |
m
i
n
^{−1}
| 0.005 |

μ
_{4}
| Degradation rate constant for c3p |
m
i
n
^{−1}
| 0.005 |

μ
_{5}
| Degradation rate constant for CEA |
m
i
n
^{−1}
| 0.005 |

Ω_{
E
Z
}
| Basal synthesis rate for c3p |
μ M·m i n^{−1}
| 0.05 |

Ω_{9}
| Basal synthesis rate for c9p |
μ M·m i n^{−1}
| 0.05 |