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Figure 4 | BMC Systems Biology

Figure 4

From: Levels of pro-apoptotic regulator Bad and anti-apoptotic regulator Bcl-xL determine the type of the apoptotic logic gate

Figure 4

Steady-state concentrations for gate OR. The presence of a single sufficiently strong input signal, p 53killer or A k tu, triggers apoptosis. Heights of bars correspond to the steady-state levels of proteins. Bars sharing adjacent sides (marked with colons and color gradient) denote complexes. To keep the convention, some bars do not start from 0. Accordingly, in (A) there are about 2 × 104 molecules of Bax:Bcl-xL complex, about 1 × 104 molecules of free Bcl-xL, about 7 × 104 molecules of Bcl-xL:Badu complex, about 13 × 104 Badp:Scaffold14-3-3 complex, and about 7 × 104 molecules of free Scaffold14-3-3. (A) The steady state levels of proteins and complexes corresponding to p 53killer = 0 and A k tu = 0 (surviving cell, in the presence of growth factors). In order to induce apoptosis, gate OR requires a single sufficiently strong signal from (B) p53killer (p 53killer = 2 × 105) or (C) Aktu (A k tu = 2 × 105). (D) Simultaneous presence of both input signals (p 53killer = 2 × 105, A k tu = 2 × 105) results in higher level of Bax than in the case of stimulation by a single signal.

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