Figure 6
Steady-state concentrations for gate AND*. Transition from OR to AND* results from the increase of Bcl-xL tot. The simultaneous presence of both input signals,p53killer and Aktu, is necessary to induce apoptosis. Heights of bars correspond to the steady state levels of proteins. Bars sharing adjacent sides (marked with colons and color gradient) denote complexes. To keep the convention, some bars do not start from 0. (A) The steady state levels of proteins and complexes corresponding to p53killer = 0 and Aktu = 0 (surviving cell, in the presence of growth factors). (B, C) A single maximal pro-apoptotic signal neither from p53killer nor from Aktu suffices to trigger apoptosis. (D) Simultaneous presence of both signals triggers apoptosis.