Table 1 Model parameters
Symbol | Value | Unit | Description |
|---|---|---|---|
s 1 | 10−2 | mlcl × s−1 | Basal BaxmRNA synthesis rate |
s 2 | 3 × 10−2 | mlcl × s−1 | p53killer-regulated BaxmRNA synthesis rate |
s 3 | 2 × 101 | mlcl × s−1 | Pro-caspases synthesis rate |
s 4 | 2 × 10−1 | s−1 | Bax protein synthesis |
M | 105 | mlcl | Michaelis–Menten coefficient for p53killer-regulated Bax transcription |
d 1 | 10−3 | s−1 | BaxmRNA degradation rate |
d 2 | 10−4 | s−1 | Bax degradation rate |
d 3 | 2 × 10−4 | s−1 | Pro-caspases and caspases degradation rate |
b 1 | 3 × 10−5 | mlcl−1s−1 | Bax–Bcl-xL binding rate |
b 2 | 3 × 10−3 | mlcl−1s−1 | Bcl-xL–Badu binding rate |
b 3 | 3 × 10−3 | mlcl−1s−1 | Badp–Scaffold14-3-3 binding rate |
u 1 | 10−4 | s−1 | Bax:Bcl-xL heterodimer unbinding rate |
u 2 | 10−4 | s−1 | Bcl-xL:Badu heterodimer unbinding rate |
u 3 | 10−4 | s−1 | Badp:Scaffold14-3-3 heterodimer unbinding rate |
p 1 | 3 × 10−10 | s−1 | Badu phosphorylation rate in Bcl-xL:Badu heterodimer (by Aktp) |
q 1 | 3 × 10−5 | s−1 | Badp dephosphorylation rate |
a 1 | 2 × 10−10 | mlcl−1s−1 | Pro-caspases activation rate (by Bax) |
a 2 | 10−12 | mlcl−2s−1 | Pro-caspases autoactivation rate |
A k t tot | 2 × 105 | mlcl | Constant pool of Akt, A k ttot=A k tu+A k tp |
| 2 × 105 | mlcl | Maximum allowed level of p 53killer |