Figure 2

Intersections between the lists of DET and DEP for the strain conditions. (A) and (B) Proportional Euler-diagrams showing the intersections between the lists of differentially expressed transcripts and proteins identified for the strain conditions. Proportional Euler-diagrams visually represent the cardinalities of sets and intersection sets of differentially expressed transcripts or proteins by area-proportional circle graphics. Each list of DE transcripts or proteins is then represented by a circle with a diameter proportional to the cardinality of the list and the overlaps between the circles are proportional to the cardinality of the intersections between the lists. For each strain condition the number of transcripts or proteins found as DE in the host response is indicated as well as the degree of overlap — quantified as the percentage of transcripts or proteins also found as differentially expressed in another condition. (C) Heatmap of the transcriptomic expression values, ratioed to mock-infected samples, for each infected sample. The heatmaps have been restricted to the lists of transcripts found as specific for each viral strain and the different subsets of transcripts specific are indicated. For each set of specific transcripts, hierarchical clustering have been performed and represented using dendrograms. Biological samples have been ordered by strain conditions, sorted by inoculation concentrations and then by increasing days post-infection. (D) Heatmaps showing the statistical over-representation of the canonical pathways based on the lists of transcripts found as differentially expressed (compared to the mock-infected conditions) for each of the 51 biological conditions. This heatmap has been restricted to only display the top canonical pathways over-represented across all the dataset.