Table 1 Functional enrichment of the eigentranscript identified in the host response kinetics to VN1203
From: Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice
Eigentranscript (No. of molecules) | Bio functions category (functions annotation p-value range) | Canonical pathway ( p-value) | Upstream regulator ( p-value of overlap) |
|---|---|---|---|
eigentranscript #1 (2706) | Embryonic development (5.55E-11–5.24E-03) | Axonal guidance signaling (8.71E-07) | NKX2-1 (5.35E-13) |
Organ development (5.55E-11–5.24E-03) | Basal cell carcinoma signaling (1.82E-05) | PPP3R1 (2.10E-11) | |
Organismal development (5.55E-11–5.24E-03) | Glutathione-mediated detoxification (6.61E-05) | DMD (1.36E-05) | |
Tissue development (5.55E-11–5.24E-03) | Xenobiotic metabolism signaling (2.19E-04) | BMP6 (6.45E-05) | |
Respiratory system development and function (1.19E-10–2.38E-03) | Tryptophan degradation (4.68E-04) | GLI1 (1.38E-04) | |
eigentranscript #2 (2826) | Cellular function and maintenance (3.38E-55–2.01E-09) | Death receptor signaling (5.01E-09) | LPS* (9.74E-111) |
Cellular function and maintenance (3.38E-55–2.01E-09) | Apoptosis signaling (7.94E-09) | IFNG (2.42E-87) | |
Hematological system development and function (1.34E-51–3.31E-09) | Role of pattern recognition receptors in recognition of bacteria and viruses (1.78E-08) | TNF (8.84E-65) | |
Tissue morphology (5.34E-51–2.48E-10) | Induction of apoptosis by HIV1 (4.07E-08) | IL1B (1.15E-56) | |
Cellular growth and proliferation (5.55E-11–5.24E-03) | Protein ubiquitination pathway (4.17E-08) | TP53 (6.72E-55) | |
eigentranscript #3 (128) | Cell cycle (1.67E-11–1.60E-02) | Pyrimidine deoxyribonucleotides de novo biosynthesis I (5.13E-05) | E2F4 (5.42E-12) |
Cell cycle (1.67E-11–1.60E-02) | T Cell receptor signaling (1.70E-04) | FOXM1 (1.84E-11) | |
Cellular development (5.83E-10–1.60E-02) | iCOS-iCOSL signaling in T helper cells (2.69E-04) | CDK4 (1.44E-10) | |
Hematological system development and function (5.83E-10–1.60E-02) | Mitotic roles of polo-like kinase (4.47E-04) | CDKN1A (1.09E-09) | |
|  | Hematopoiesis (5.83E-10–1.60E-02) | Regulation of IL-2 expression in activated and anergic T lymphocytes (8.51E-04) | CCND1 (1.66E-09) |