SignaLink 2 – a signaling pathway resource with multi-layered regulatory networks

BMC Systems Biology

Table 1 Detailed statistics of SignaLink 2

Species	C. elegans		D. melanogaster		H. sapiens
Layers	Nodes	Edges	Nodes	Edges	Nodes	Edges
Pathway members	198	253	210	260	1,150	1,640
Pathway regulators	0	0	0	0	751	2,122
Post-translational modifiers	916	3,072	1,713	6,896	4,682	82,852
Directed protein-protein interactors	49	47	128	171	951	3,252
Undirected protein-protein interactors	100	245	166	496	1,387	6,086
TF regulators	152	187	998	16,319	2,585	30,736
miRNA regulators	806	9,658	939	5,308	2,844	245,857
TFs of miRNAs	25	19	0	0	716	5,209

SignaLink 2 contains different amounts of proteins/miRNAs in each layer in each species, according to the data from the literature and external sources. See the main text for details on the layers and sources. For C. elegans and D. melanogaster, no data was available for pathway regulator scaffold proteins and for TFs that regulate miRNAs.

ISSN: 1752-0509