Regulatory circuit of cell cycle transcription factors. (A) mRNA expression intensity of newly predicted and known cell cycle genes. (B) Normalization scores (NS) of key genomic features (both transcription factor binding scores and motif matching scores) in promoters of 9 key cell cycle transcription factors. Asterisk denotes regulatory relationship passing certain criteria (see Methods). (C) Inferred regulatory circuit of the 9 TFs. (D) ROC curve using training data from protein feature based method.