Time-course profiles of the state trajectories for Per mRNA. (A) Increasing relative error, ξ, with. Possible state variable values are shown as shaded regions, obtained by filling between the 5 th and 95 th percentile for values at each time for 2000 independent parameter estimations. Increasing ξ results in larger deviations from the original model trajectory, shown as a dashed black line. (B) Decreasing number of measurement points,, each with ξ=0.15. Higher results in trajectories closer to the true trajectory.