Table 1 Nominal value for the parameters and MINLP best solution

k ₂

5.18E+07

4.74E+07

k ₃

9.76E+01

1.20E+02

α

5.79E-02

5.23E-02

k _tr

1.00E+03

8.66E+02

k _tl

4.96E+03

4.28E+03

k _{t l 2}

1.03E+03

1.27E+03

k _{t l 3}

2.05E+03

1.64E+03

k _z

4.99E+01

6.06E+01

k _{d 2}

1.00E+01

1.25E+01

D N A ₀

6.16E-04

7.08E-04

K _a

1.82E-07

2.11E-07

K

1.00E+03

8.48E+02

k _d

1.18E+00

9.55E-01

k _hy

2.00E+06

1.76E+06

k _transf

9.74E-01

8.07E-01

k _degf

1.36E-01

1.84E-01

k _hy

-

-

n₁:

3

3

n₂:

1

1

n₃:

2

3

n₄:

3

3

n₅:

0

0

b i n₁:

1

1

b i n₂:

1

1

b i n₃:

0

0