Figure 1From: Transdifferentiation of pancreatic cells by loss of contact-mediated signalingGene regulation and lateral signaling network. In cell i, the common names of the transcription factors are used. In cell j, these are replaced by the respective model variables. Cells i and j are coupled by lateral inhibition of factors X, and by lateral stabilization between factors Y. For each cell, the upstream factor A induces expression of X and Y, while X also induces Z expression, which activates itself. Both endocrine factors X and Z antagonize exocrine factor Y. Once differentiated, the markers Y and Z down-regulate A. Parameters in small lower case represent strengths of the interactions.Back to article page