Figure 3

Dynamics of cell fate control. Dynamics of cell fate decisions during development (left column) and lineage conversion (middle and right columns). (A) Sketch of cell-cell signaling condition. (B) Expression of transcription factors over time. A: Hnf6, X: Ngn3, Y: Ptf1a, Z: Isl1. Black lines in B’ depict population averages. (C) Emergent spatial patterns, representing cell fates by colors. Color coding: Y⁺ acinar cells are red, Z⁺ islet cells are blue, and Y⁻Z⁻ cells are white. Initial condition for development is A=1,X=Y=Z=0 and for conversion is Y=1,A=X=Y=0. Parameters as in Table 1. Movies of the spatiotemporal dynamics are available as Additional files (2, 3 and 4).