Skip to main content

Table 1 Variables and parameters

From: Transdifferentiation of pancreatic cells by loss of contact-mediated signaling

 

Symbol

Description

Value

 
   

Embryo

Adult

Variables

A

Expression of transcription factor Hnf6

1

0

 

X

Expression of transcription factor Ngn3

0

0

 

Y

Expression of transcription factor Ptf1a

0

1

 

Z

Expression of transcription factor Isl1

0

0

 

X Ì„

Average Ngn3 expression in neighboring cells

0

0

 

Y Ì„

Average Ptf1a expression in neighboring cells

0

1

Parameters

a

Strength of lateral inhibition X⊩⊣X

1000

 
 

b

Strength of lateral stabilization Y⇔Y

2000

 
 

c

Strength of inhibition X⊣Y and Z⊣Y

500

 
 

q

Strength of induction A→X and A→Y

10−4

 
 

r

Strength of inhibition Y⊣A and Z⊣A

100

 
 

s

Strength of autoactivation Z→Z

50

 
 

n

Hill coefficient, nonlinearity of reactions

3

 
 

η x

Noise amplitude on X

10−3

 
 

η y

Noise amplitude on Y

10−3

 
  1. Parameters and initial conditions of the mathematical model (equation 1-4). Parameter values are chosen identical for embryonic and adult conditions, configured with different initial conditions.