Table 4 Gene enrichment analysis (HER2+ vs. HER2-)
From: New network topology approaches reveal differential correlation patterns in breast cancer
Category | Catalog | DCloc | DCglob | ||
|---|---|---|---|---|---|
N | p | N | p | ||
Translational elongation | GOTERM_BP_FAT | 57 | 1.5E-32 | 14 | 3.1E-01 |
Ribonucleoprotein | SP_PIR_KEYWORDS | 83 | 7.1E-31 | 46 | 1.2E-09 |
Ribosome | KEGG_PATHWAY | 55 | 4.0E-30 | 14 | 1.8E-01 |
Acetylation | SP_PIR_KEYWORDS | 303 | 8.5E-20 | 276 | 2.3E-28 |
Mitotic cell cycle | GOTERM_BP_FAT | 77 | 6.8E-13 | 65 | 7.8E-12 |
Regulation of ubiquitin-protein | GOTERM_BP_FAT | 27 | 3.3E-09 | 17 | 6.5E-04 |
ligase activity during | |||||
mitotic cell cycle | |||||
Immune response | GOTERM_BP_FAT | 98 | 1.0E-08 | n.s | |
Oxidative phosphorylation | KEGG_PATHWAY | 28 | 1.7E-04 | 30 | 4.5E-08 |
Mitochondrion | GOTERM_CC_FAT | 93 | 4.0E-01 | 106 | 6.6E-07 |
Proteasomal ubiquitin-depend- | GOTERM_BP_FAT | 27 | 2.7E-06 | 20 | 8.4E-04 |
ent protein catabolic process | |||||
Mitochondrial membrane part | GOTERM_CC_FAT | 26 | 1.3E-04 | 25 | 4.5E-06 |
MHC protein complex | GOTERM_CC_FAT | 13 | 3.5E-04 | 7 | 1.7E-01 |
Growth factor binding | GOTERM_MF_FAT | 22 | 8.5E-03 | n.s | |
NADH dehydrogenase activity | GOTERM_MF_FAT | 10 | 7.6E-02 | 11 | 2.4E-03 |
ATP synthesis coupled | GOTERM_BP_FAT | 12 | 2.7E-02 | 12 | 5.9E-03 |
electron transport | |||||
Anti-apoptosis | GOTERM_BP_FAT | 30 | 5.0E-02 | n.s | |