Cluster | Marker gene | Marker gene |
#
C
|
#
M
| #(C∩M) |
p
|
|---|
| | description | reference | | | | |
|---|
1 | IAC | Celis et al. [37] | 11 | 32 | 5 | 3.3E-11 |
2 | HER2+ | Staaf et al. [39] | 12 | 15 | 4 | 6.2E-10 |
3 | AR responsive | Doane et al. [40] | 47 | 70 | 19 | 5.2E-32 |
5 | FOXC1 subtype | Ray et al. [41] | 13 | 17 | 3 | 5.6E-07 |
- Analysis of the genes identified by DCglob that showed higher correlation in ER- compared to ER+ breast cancer. The gene clusters (C) were compared to lists of marker genes (M) from the literature. Let #C denote the number of genes in the clusters, #M the number of marker genes and #(C ∩M) the number of genes in the intersection. The significance of enrichment was assessed using Fisher’s exact test. IAC invasive apocrine carcinomas, AR androgen receptor.
