Overlap analysis between blood and brain regions. Numbers of significant DEGs (a), DEGOs (b), and DEPATHs (c) are listed in blue on the diagonal, while hyper geometric p-values are listed in the off-diagonal. P-values ≤ 0.05 are considered significant (cells highlighted in red). We consider the DEPATH overlap between hippocampus and stria terminalis to be marginally significant (red font), as it has a p-value ≤ 0.1 and is supported by a highly significant DEG overlap between the same tissues. (HB: hemibrain (hemisphere), AY: amygdala, HS: hippocampus, MPFC: medial prefrontal cortex, VS: ventral striatum, SE: septal region and ST: stria terminalis).