Figure 2

Blood-brain network. (a) nine expression modules resulted from consensus feature elimination; their brain-specific expression locations are indicated with numbered blue circles. Time-specific blood expression patterns of each module are displayed using average time curves in the form of expression panels. (b) the blood expression level of each gene in the nine modules is indicated with a colored circle. Known protein-protein interactions (PPIs) are marked by lines connecting genes—blue lines denote within-module interactions, while gray lines denote between-module interactions. (c) the putative biological functions of the expression modules are listed (as inferred using the KEGG annotation). (HB: hemibrain (hemisphere), AY: amygdala, HS: hippocampus, MPFC: medial prefrontal cortex, VS: ventral striatum, SE: septal region and ST: stria terminalis; 5D-1D/10D: 5 day treatment, 1 day/10 day recovery, 10D-1D/ 6 W: 10 day treatment, 1 day/6 week recovery).