Skip to main content
Figure 1 | BMC Systems Biology

Figure 1

From: Post-translational regulation enables robust p53 regulation

Figure 1

The p53-Mdm2 Feedback Loop. (A) p53 transcriptionally activates Mdm2, while Mdm2 degrades p53. (B) The p53 and Mdm2 levels oscillate upon DNA damage [21]. (C) Under normal conditions, Mdm2 is not suppressed by ATM and the intact feedback rejects disturbances. Upon DNA damage when p53 oscillates, the feedback is suppressed to allow p53 oscillation.

Back to article page