Gene regulatory network (GRN) of AgMNPV-2D infecting UFL-AG-286 cells generated with Cytoscape v2.8.0. A single component network shows the directed links (arrow edges) among 149 ORFs. Nodes (ORFs) have sizes proportional to their betweenness centrality (BC) and darkness proportional to stress coefficient (SC), both of which indicate node importance in the GRN. Five communities (I-V) were identified with the GLay clustering method, which indicate modules of highly interconnected nodes. Numbers correspond to ORFs in the AgMNPV-2D genome (see Additional file 1: Table S1) and the 37 genes shared among all baculoviruses are colored in red.