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Table 1 Maximum sensitivity for l -glutamic acid production

From: Analysis of l-glutamic acid fermentation by using a dynamic metabolic simulation model of Escherichia coli

No. Gene or operon Gene product Maximum sensitivity Scale factor
1 icdA isocitrate dehydrogenase 0.33615 1000
2 aceBAK malate synthase, isocitrate lyase, isocitrate dehydrogenase kinase/phosphatase 0.27963 0.001
3 iclR isocitrate lyase regulator 0.27693 1000
4 gdhA glutamate dehydrogenase 0.21119 1000
5 gltA citrate synthase 0.17565 1000
6 fba fructose bisphosphate aldolase 0.09989 400
7 pdhR pyruvate dehydrogenase complex regulator 0.09614 3
8 tpiA triose phosphate isomerase 0.09399 4
9 ptsG glucose-specific PTS permease, IICB domain 0.07520 500
10 gpmA phosphoglycerate mutase 0.06702 0.001
11 gapA glyceraldehyde-3-phosphate dehydrogenase 0.06605 600
12 epd-pgk glyceraldehyde-3-phosphate dehydrogenase, phosphoglycerate kinase 0.06446 900
13 crr glucose-specific PTS permease, IIA domain 0.05030 1000
14 pykF pyruvate kinase 0.03785 5
15 eno enolase 0.03391 0.001