Figure 1From: The development of a fully-integrated immune response model (FIRM) simulator of the immune response through integration of multiple subset modelsThe reconstructed FIRM network. A. The final FIRM formulation includes inactive fluxes and nodes that are included for completeness in this figure. Symbols are as follows: TUMOR, tumor mass; DEBRIS, tumor cell debris; MAPC, antigen-presenting macrophages; MA, activated macrophages; MR, resting macrophages; MI, infected macrophages; PI, intracellular bacteria; PE, extracellular bacteria; IDC, immature dendritic cells; MDC, mature dendritic cells; T, naïve T-cells; TCP, cytotoxic precursor T-cells; TC, cytotoxic T-cells; THP, helper precursor T-calls TH1, T-helper 1 cells; TH2, T-helper 2 cells; AB, antibody; B, naïve B-cells; BA, activated B-cells; BM, memory B-cells; BP, plasma B-cells; Treg, regulatory T-cells. See the Supplemental Material for the full details. B. The cytokine activity of the FIRM network. Solid green arrows represent production. Dashed green arrows represent up-regulation of a flux, and dashed red arrows represent down-regulation of a flux. The graph is a superset of Figure 1A, where cytokines are superimposed to the previously defined cell populations. Symbols are as follows: I12, interleukin-12; Iγ, interferon-gamma; I10, interleukin-10; I4, interleukin 4; TGF-β, tumor growth factor beta.Back to article page