Figure 3

The individual areas of influence of the three original models (MK, DB and BL) in relation to the FIRM network structure. There was overlap in the content of the original models, exemplified here by the overlapping shaded areas of the MK ([10]) and DB ([5]) models (light green). Nodes not encompassed by a shaded area are inactive in the final FIRM structure but have been identified as connections among models and are reported for completeness. See the Supplemental Material (Additional file 1) for full details on inactive fluxes and nodes.