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Figure 4 | BMC Systems Biology

Figure 4

From: The development of a fully-integrated immune response model (FIRM) simulator of the immune response through integration of multiple subset models

Figure 4

Scope and details of the BL model in the context of the FIRM network. The model [8] included detailed information on the interactions of antigens, antibodies, and B-cell receptor sites of the humoral response. Symbols are as follows: B, naïve B-cells; BA, activated B-cells; BP, plasma B-cells; BM, memory B-cells. Bivalent antibodies are released by BA and BP in the lymphoid B organs and bind antigens both in blood and lung (target organ) tissues. The antigen binds to naïve and activated B-cells and stimulates the formation of antibody.

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