Figure 4From: The development of a fully-integrated immune response model (FIRM) simulator of the immune response through integration of multiple subset modelsScope and details of the BL model in the context of the FIRM network. The model [8] included detailed information on the interactions of antigens, antibodies, and B-cell receptor sites of the humoral response. Symbols are as follows: B, naïve B-cells; BA, activated B-cells; BP, plasma B-cells; BM, memory B-cells. Bivalent antibodies are released by BA and BP in the lymphoid B organs and bind antigens both in blood and lung (target organ) tissues. The antigen binds to naïve and activated B-cells and stimulates the formation of antibody.Back to article page