Reconstruction of the experimentally supported human protein interactome: what can we learn?

BMC Systems Biology

Table 1 The size of the reconstructed direct PPI network for the manually reviewed human “complete” proteome

	Number of UniProt Identifiers⁽¹⁾	Number of Direct PPIs⁽²⁾(x)	Number of Supporting Publications (y)	Mean Number of PPIs per Publication (x/y)
UniProtKB manually reviewed human “complete” proteome	20242	N/A	N/A	N/A
HPRD	9303	37152	19267	1.93
IntAct	6666	19425	1598	12.15
MINT	6102	16147	2398	6.73
DIP	1795	2609	1180	2.21
BioGRID	9265	42647	13818	3.08
PICKLE	11827	75965	26689	2.85

The size of the reconstructed network is compared to the size of the normalized to the UniProt identifier level source PPI datasets for the defined reference protein set. N/A: not applicable.
⁽¹⁾members of the UniProtKB manually reviewed human “complete” proteome.
⁽²⁾between members of the UniProtKB manually reviewed human “complete” proteome.

ISSN: 1752-0509