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Figure 3 | BMC Systems Biology

Figure 3

From: Identifying reaction modules in metabolic pathways: bioinformatic deduction and experimental validation of a new putative route in purine catabolism

Figure 3

Genomic context of genes encoding uncharacterized dehydrogenases (DHases) X1 sequences and their interactions with neighbours. A. Genetic neighbourhoods of DHases X1 found in various organisms are schematized. The order and spacing of the genes are not respected for the sake of clarity. Except for E. coli where the gene name is given, the names in boxes are the UniprotKB accession number of the corresponding protein. The organisms mentioned twice with numbers (1) and (2) display two different neighbourhoods in different genome locations. “XDHase” stands for the full set of genes (xdhA, xdhB, xdhC) encoding the three subunits of xanthine dehydrogenase. B. The detected protein-protein interactions are summarized as a synthesis of individual data published by STRING database [23]. The E. coli gene names that are syntenic are in bold and accompanied by their Blattner identifier (b2870 and following) as published in [24]. The gene products that catalyze reactions shown in Figure 1 are highlighted by their respective box number (indicated in yellow circles). The different genes encoding a carbamoyltransferase are shown with the label TCase in green rectangles.

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