Figure 4

Differential pathway and gene expression patterns in glioblastoma subgroups. a) Alternating pathway aberration patterns for nine pathways are shown for the GBM subgroups. Highlighted are Immune response pathway (purple) that is depleted in subgroup 12, Protein kinase pathway (yellow) enriched in subgroup 6, and Wnt signalling pathway (blue) enriched in subgroup 9. Shown in panels below are mean expression levels in subgroups for the genes in three highlighted pathways: b) Immune response, c) Protein kinase cascade and d) Wnt signalling pathway. E) Expression levels of Wnt signalling pathway genes in individual samples demonstrate the consistency of gene expression patterns within an enriched subgroup.